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The theoretical concern exists in the literature, but it has not translated into a clinical issue in her experience

In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention

There are a number of methods to reduce the out-of-pocket cost of these drugs, including subsidies and increasing insurance coverage, but Govind Persad of the University of Colorado Law School noted that it is also critical to ensure that incentivesmany of which are monetaryremain for drug developers to continue to innovate in this field while simultaneously maximizing patient access now

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